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Clinical Trial
. 1998 Oct 16;282(5388):476-80.
doi: 10.1126/science.282.5388.476.

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine

R Wang  1 , D L Doolan, T P Le, R C Hedstrom, K M Coonan, Y Charoenvit, T R Jones, P Hobart, M Margalith, J Ng, W R Weiss, M Sedegah, C de Taisne, J A Norman, S L Hoffman
Affiliations
Clinical Trial

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine

R Wang et al. Science. .

Abstract

CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+ T cell responses. Malaria-naïve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8+ T cell-dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naïve humans of the induction of CD8+ CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.

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