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Review
. 1998:67:1-25.
doi: 10.1146/annurev.biochem.67.1.1.

HIV-1: fifteen proteins and an RNA

A D Frankel  1 , J A Young
Affiliations
Review

HIV-1: fifteen proteins and an RNA

A D Frankel et al. Annu Rev Biochem. 1998.

Abstract

Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins. Substantial progress has been made toward understanding the function of each protein, and three-dimensional structures of many components, including portions of the RNA genome, have been determined. This review describes the function of each component in the context of the viral life cycle: the Gag and Env structural proteins MA (matrix), CA (capsid), NC (nucleocapsid), p6, SU (surface), and TM (transmembrane); the Pol enzymes PR (protease), RT (reverse transcriptase), and IN (integrase); the gene regulatory proteins Tat and Rev; and the accessory proteins Nef, Vif, Vpr, and Vpu. The review highlights recent biochemical and structural studies that help clarify the mechanisms of viral assembly, infection, and replication.

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