Review
doi: 10.1016/s0014-5793(98)00856-4.
A novel aspect of calpain activation
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- PMID: 9738920
- DOI: 10.1016/s0014-5793(98)00856-4
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Review
A novel aspect of calpain activation
FEBS Lett.
.
Free article
Abstract
Calpain, a Ca2+-dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure-function relationship of calpain and X-ray analysis of its Ca2+-binding domain have revealed hitherto unknown features of the regulation of calpain activity. A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure-function studies of calpain, and its implications are discussed.
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