doi: 10.1016/s0952-7915(98)80124-6.
HLA supertypes and supermotifs: a functional perspective on HLA polymorphism
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- PMID: 9722926
- DOI: 10.1016/s0952-7915(98)80124-6
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HLA supertypes and supermotifs: a functional perspective on HLA polymorphism
Curr Opin Immunol.
1998 Aug.
Abstract
A large fraction of HLA class I, and possibly class II, molecules can be classified into relatively few supertypes, characterized by overlapping peptide-binding repertoires and consensus B- and F-pocket structures. Cross-binding peptides are frequently recognized by specific T cells in the course of natural disease processes and in the context of multiple HLA molecules, validating the concept of HLA supertypes at the functional level.
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