Review
doi: 10.1016/s0952-7915(98)80118-0.
Protective immunity induced by live attenuated simian immunodeficiency virus
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- PMID: 9722920
- DOI: 10.1016/s0952-7915(98)80118-0
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Review
Protective immunity induced by live attenuated simian immunodeficiency virus
Curr Opin Immunol.
1998 Aug.
Abstract
Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.
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