Review
doi: 10.1016/s0009-9120(98)00045-9.
Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
Affiliations
- PMID: 9721431
- DOI: 10.1016/s0009-9120(98)00045-9
Item in Clipboard
Review
Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
Clin Biochem.
1998 Jul.
Abstract
Rapamune is a novel immunosuppressive agent in Phase III clinical trial in renal transplantation. Its unique mechanism of action has created great interest in its use as a biochemical probe of signal transduction pathways that has provided insight into its molecular mechanism of action. This article reviews the current state of our understanding of the mechanism of action of rapamune.
Similar articles
-
Mechanism of action of the immunosuppressant rapamycin.Life Sci. 1996;58(5):373-95. doi: 10.1016/0024-3205(95)02233-3. Life Sci. 1996. PMID: 8594303 Review.
-
Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin.Immunol Res. 1994;13(2-3):110-6. doi: 10.1007/BF02918272. Immunol Res. 1994. PMID: 7539823 Review.
-
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.J Immunol. 1999 Mar 1;162(5):2775-84. J Immunol. 1999. PMID: 10072524
-
Mechanism of action of rapamycin (Sirolimus, Rapamune).Transplant Proc. 1996 Apr;28(2):964-9. Transplant Proc. 1996. PMID: 8623482 Review. No abstract available.
-
Sirolimus. AY 22989, NSC 226080, NSC 606698, rapamycin, Rapamune.Drugs R D. 1999 Jan;1(1):100-7. doi: 10.2165/00126839-199901010-00033. Drugs R D. 1999. PMID: 10566001 No abstract available.
Cited by
-
Safety and efficacy of immunomodulators and biologics during pregnancy and lactation for the treatment of inflammatory bowel disease.Expert Opin Drug Saf. 2012 Nov;11(6):947-57. doi: 10.1517/14740338.2012.720970. Epub 2012 Sep 6. Expert Opin Drug Saf. 2012. PMID: 22954378 Free PMC article. Review.
-
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.Br J Pharmacol. 2001 Jul;133(6):875-85. doi: 10.1038/sj.bjp.0704142. Br J Pharmacol. 2001. PMID: 11454661 Free PMC article.
-
Effects of rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood.Cell Prolif. 2006 Apr;39(2):117-25. doi: 10.1111/j.1365-2184.2006.00375.x. Cell Prolif. 2006. PMID: 16542347 Free PMC article.
-
Exploiting cellular pathways to develop new treatment strategies for AML.Cancer Treat Rev. 2010 Apr;36(2):142-50. doi: 10.1016/j.ctrv.2009.12.004. Epub 2010 Jan 6. Cancer Treat Rev. 2010. PMID: 20056334 Free PMC article. Review.
-
Pharmacogenomics of Old and New Immunosuppressive Drugs for Precision Medicine in Kidney Transplantation.J Clin Med. 2023 Jul 3;12(13):4454. doi: 10.3390/jcm12134454. J Clin Med. 2023. PMID: 37445489 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
