A tutorial on the diffusibility and reactivity of free nitric oxide
- PMID: 9701041
- DOI: 10.1006/niox.1996.0112
A tutorial on the diffusibility and reactivity of free nitric oxide
Abstract
In this review, I consider the quantitative consequences of the diffusion of free NO in determining its biological actions. Several studies have measured the extent to which NO diffuses away from an NO-producing cell, and the distance of its diffusion is quite large, on the order of 100-200 microm. This wide diffusibility is consistent also with the high value for its diffusion constant, 3300 microm2/s. Mathematical simulations based on this wide diffusibility suggest that, within spatial limits of approximately 0.3-0.4 mm, the actions of free NO are dictated by the total number of NO-producing cells within this location as opposed to where the NO-producing cells are located within this space. These results suggest that the actions of NO are surprisingly long range and the diffusion of NO is an important determinant of its biological actions. Thus, the effects of NO on individual target cells may be determined more by each cell's preprogrammed characteristic response to NO than by proximity to an NO source. In addition, scavenging of NO by hemoglobin in blood vessels should represent a significant sink for its scavenging, posing difficulty for the postulate that only free NO functions as EDRF.
Similar articles
-
Simulation of the diffusion and reaction of endogenously produced nitric oxide.Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8137-41. doi: 10.1073/pnas.91.17.8137. Proc Natl Acad Sci U S A. 1994. PMID: 8058769 Free PMC article.
-
Effective diffusion distance of nitric oxide in the microcirculation.Am J Physiol. 1998 May;274(5):H1705-14. doi: 10.1152/ajpheart.1998.274.5.H1705. Am J Physiol. 1998. PMID: 9612383
-
Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics.Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):697-705. doi: 10.1161/01.ATV.0000204350.44226.9a. Epub 2006 Jan 19. Arterioscler Thromb Vasc Biol. 2006. PMID: 16424350 Review.
-
Connecting the chemical and biological properties of nitric oxide.Chem Res Toxicol. 2012 May 21;25(5):975-89. doi: 10.1021/tx300042g. Epub 2012 Apr 6. Chem Res Toxicol. 2012. PMID: 22449080 Review.
-
[Mathematical modeling of non-stationary spatial gradients of nitric oxide in the muscle wall of blood vessels].Biofizika. 2003 Jan-Feb;48(1):91-6. Biofizika. 2003. PMID: 12630121 Russian.
Cited by
-
What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology.J Biol Chem. 2010 Jun 25;285(26):19699-704. doi: 10.1074/jbc.R110.101618. Epub 2010 Apr 21. J Biol Chem. 2010. PMID: 20410298 Free PMC article. Review.
-
Sustained release nitric oxide from long-lived circulating nanoparticles.Free Radic Biol Med. 2010 Aug 15;49(4):530-8. doi: 10.1016/j.freeradbiomed.2010.04.034. Epub 2010 May 9. Free Radic Biol Med. 2010. PMID: 20460149 Free PMC article.
-
Nitric oxide in cellular adaptation and disease.Redox Biol. 2020 Jul;34:101550. doi: 10.1016/j.redox.2020.101550. Epub 2020 Apr 25. Redox Biol. 2020. PMID: 32438317 Free PMC article. Review.
-
Biodegradable poly(lactic-co-glycolic acid) microspheres loaded with S-nitroso-N-acetyl-D-penicillamine for controlled nitric oxide delivery.J Control Release. 2016 Mar 10;225:133-9. doi: 10.1016/j.jconrel.2015.12.056. Epub 2016 Jan 5. J Control Release. 2016. PMID: 26763376 Free PMC article.
-
Identification of a critical lipid ratio in raft-like phases exposed to nitric oxide: An AFM study.Biophys J. 2021 Aug 3;120(15):3103-3111. doi: 10.1016/j.bpj.2021.06.009. Epub 2021 Jun 29. Biophys J. 2021. PMID: 34197799 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
