Review
doi: 10.1016/s0968-0004(98)01223-7.
Protein-PCNA interactions: a DNA-scanning mechanism?
Affiliations
- PMID: 9697409
- DOI: 10.1016/s0968-0004(98)01223-7
Item in Clipboard
Review
Protein-PCNA interactions: a DNA-scanning mechanism?
Trends Biochem Sci.
1998 Jul.
Abstract
Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates.
Similar articles
-
The archaeal PCNA proteins.Biochem Soc Trans. 2011 Jan;39(1):20-4. doi: 10.1042/BST0390020. Biochem Soc Trans. 2011. PMID: 21265741 Review.
-
Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.Exp Cell Res. 2004 Feb 15;293(2):357-67. doi: 10.1016/j.yexcr.2003.10.025. Exp Cell Res. 2004. PMID: 14729473
-
PCNA binding proteins.Front Biosci. 1999 Dec 1;4:D849-58. doi: 10.2741/tsurimoto. Front Biosci. 1999. PMID: 10577396 Review.
-
DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories.EMBO J. 1998 Jul 1;17(13):3786-95. doi: 10.1093/emboj/17.13.3786. EMBO J. 1998. PMID: 9649448 Free PMC article.
-
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.Curr Biol. 1995 Mar 1;5(3):275-82. doi: 10.1016/s0960-9822(95)00058-3. Curr Biol. 1995. PMID: 7780738
Cited by
-
Developing peptide-based multivalent antagonists of proliferating cell nuclear antigen and a fluorescence-based PCNA binding assay.Anal Biochem. 2012 Aug 1;427(1):69-78. doi: 10.1016/j.ab.2012.04.018. Epub 2012 Apr 20. Anal Biochem. 2012. PMID: 22522186 Free PMC article.
-
Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress.Protein Expr Purif. 2010 May;71(1):54-61. doi: 10.1016/j.pep.2009.12.001. Epub 2009 Dec 6. Protein Expr Purif. 2010. PMID: 19995609 Free PMC article.
-
Stress sensor Gadd45 genes as therapeutic targets in cancer.Cancer Ther. 2009;7(A):268-276. Cancer Ther. 2009. PMID: 19652693 Free PMC article.
-
Prognostic value and underlying mechanism of KIAA0101 in hepatocellular carcinoma: database mining and co-expression analysis.Aging (Albany NY). 2020 Aug 27;12(16):16420-16436. doi: 10.18632/aging.103704. Epub 2020 Aug 27. Aging (Albany NY). 2020. PMID: 32855364 Free PMC article.
-
Gadd45 in the response of hematopoietic cells to genotoxic stress.Blood Cells Mol Dis. 2007 Nov-Dec;39(3):329-35. doi: 10.1016/j.bcmd.2007.06.006. Epub 2007 Jul 30. Blood Cells Mol Dis. 2007. PMID: 17659913 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
