Matrix metalloproteinases: the clue to intervertebral disc degeneration?
- PMID: 9682320
- DOI: 10.1097/00007632-199807150-00021
Matrix metalloproteinases: the clue to intervertebral disc degeneration?
Abstract
Study design: A review of the current literature on the role of matrix metalloproteinases in intervertebral disc degeneration.
Objective: To detail the characteristics of matrix metalloproteinases (classification, structure, substrate specificity and regulation) and to report previous studies of intervertebral discs.
Summary of background data: Degeneration of the intervertebral disc, a probable prerequisite to disc herniation, is a complex phenomenon, and its physiopathologic course remains unclear. Matrix metalloproteinases probably play an important role but have received sparse attention in the literature.
Methods: A systematic review of studies reporting a role of matrix metalloproteinases in intervertebral disc degeneration.
Results: In several studies, investigators have reported the presence of proteolytic enzymes from disc culture systems and disc tissue extracts in degenerated human intervertebral discs, especially collagenase-1 (MMP-1) and stromelysin-1 (MMP-3). The matrix metalloproteinases are regulated by specific inhibitors (tissue inhibitors of metalloproteinases, or TIMPS), cytokines (interleukin-1), and growth factors.
Conclusions: This field of application is of particular interest because conventional treatments are disappointing in chronic low back pain. Clinical trials with specific inhibitors of metalloproteinases are beginning in osteoarthritis.
Similar articles
-
Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases.Spine (Phila Pa 1976). 1997 May 15;22(10):1065-73. doi: 10.1097/00007632-199705150-00003. Spine (Phila Pa 1976). 1997. PMID: 9160463
-
Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis.Spine (Phila Pa 1976). 1997 Dec 15;22(24):2877-84. doi: 10.1097/00007632-199712150-00010. Spine (Phila Pa 1976). 1997. PMID: 9431623
-
Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption.Spine (Phila Pa 1976). 2001 Jul 15;26(14):1522-7. doi: 10.1097/00007632-200107150-00004. Spine (Phila Pa 1976). 2001. PMID: 11462080
-
Intervertebral disk degeneration and herniation: the role of metalloproteinases and cytokines.Joint Bone Spine. 2001 Dec;68(6):547-53. doi: 10.1016/s1297-319x(01)00324-4. Joint Bone Spine. 2001. PMID: 11808997 Review.
-
Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration.Spine J. 2013 Mar;13(3):331-41. doi: 10.1016/j.spinee.2012.02.027. Epub 2013 Jan 29. Spine J. 2013. PMID: 23369495 Free PMC article. Review.
Cited by
-
Role of IL3RA in a Family with Lumbar Spinal Stenosis.Int J Mol Sci. 2024 Oct 10;25(20):10915. doi: 10.3390/ijms252010915. Int J Mol Sci. 2024. PMID: 39456698 Free PMC article.
-
Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration.Antioxidants (Basel). 2022 Aug 14;11(8):1571. doi: 10.3390/antiox11081571. Antioxidants (Basel). 2022. PMID: 36009290 Free PMC article. Review.
-
Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside.Oxid Med Cell Longev. 2020 Feb 1;2020:7540197. doi: 10.1155/2020/7540197. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32089778 Free PMC article.
-
Biologic response of human intervertebral disc cells to gene therapy cocktail.Spine (Phila Pa 1976). 2008 Aug 1;33(17):1850-5. doi: 10.1097/BRS.0b013e31817e1cd7. Spine (Phila Pa 1976). 2008. PMID: 18622355 Free PMC article.
-
Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways.Arthritis Res Ther. 2013 Aug 22;15(4):R94. doi: 10.1186/ar4274. Arthritis Res Ther. 2013. PMID: 23968377 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
