Review
doi: 10.1046/j.1432-1327.1998.2530531.x.
Regulation of translation initiation factors by signal transduction
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- PMID: 9654048
- DOI: 10.1046/j.1432-1327.1998.2530531.x
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Review
Regulation of translation initiation factors by signal transduction
Eur J Biochem.
.
Free article
Abstract
Regulation of eukaryotic translation initiation is a process that requires collaboration between multiple proteins. The cap-binding factor eukaryotic initiation factor (eIF)4E, its binding protein 4E-BP1, and the guanine-nucleotide-exchange factor eIF2B play important roles in the regulation of the rate of protein synthesis. This review describes the regulation of the activity of these three proteins and the signal-transduction pathways involved therein.
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