Review
doi: 10.1016/s0955-0674(98)80149-x.
Mechanisms and consequences of activation of protein kinase B/Akt
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- PMID: 9561851
- DOI: 10.1016/s0955-0674(98)80149-x
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Review
Mechanisms and consequences of activation of protein kinase B/Akt
Curr Opin Cell Biol.
1998 Apr.
Abstract
Protein kinase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin.
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