Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus
- PMID: 9545226
- DOI: 10.1126/science.280.5362.450
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus
Abstract
Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II-restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation in cortical thymic epithelial cells (cTECs), but not in bone marrow (BM)-derived antigen-presenting cells (APCs). Consequently, positive selection of CD4+ T cells was reduced. Because different cysteine proteinases are responsible for specific Ii degradation steps in cTECs and BM-derived APCs, the proteolytic environment in cells mediating positive and negative selection may be distinct. The identification of a protease involved in class II presentation in a tissue-specific manner suggests a potential means of manipulating CD4+ T cell responsiveness in vivo.
Comment in
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Proteases, processing, and thymic selection.Science. 1998 Apr 17;280(5362):394-5. doi: 10.1126/science.280.5362.394. Science. 1998. PMID: 9575085 No abstract available.
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