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. 1998;39(3):223-32.
doi: 10.1002/(SICI)1097-0169(1998)39:3<223::AID-CM5>3.0.CO;2-5.

Glutamylation of centriole and cytoplasmic tubulin in proliferating non-neuronal cells

Y Bobinnec  1 , M Moudjou, J P Fouquet, E Desbruyères, B Eddé, M Bornens
Affiliations

Glutamylation of centriole and cytoplasmic tubulin in proliferating non-neuronal cells

Y Bobinnec et al. Cell Motil Cytoskeleton. 1998.

Abstract

We have examined the distribution of glutamylated tubulin in non-neuronal cell lines. A major part of centriole tubulin is highly modified on both the alpha- and beta-tubulin subunits, whereas a minor part of the cytoplasmic tubulin is slightly modified, on the beta-tubulin only. Furthermore, we observed that tubulin glutamylation varies during the cell cycle: an increase occurs during mitosis on both centriole and spindle microtubules. In the spindle, this increase appears more obvious on the pole-to-pole and kinetochore microtubules than on the astral microtubules. The cellular pattern and the temporal variation of this post-translational modification contrast with other previously described tubulin modifications. The functional significance of this distribution is discussed.

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