Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Feb 3;95(3):1259-64.
doi: 10.1073/pnas.95.3.1259.

Fine structure of neural spiking and synchronization in the presence of conduction delays

G B Ermentrout  1 , N Kopell
Affiliations

Fine structure of neural spiking and synchronization in the presence of conduction delays

G B Ermentrout et al. Proc Natl Acad Sci U S A. .

Abstract

Hippocampal networks of excitatory and inhibitory neurons that produce gamma-frequency rhythms display behavior in which the inhibitory cells produce spike doublets when there is strong stimulation at separated sites. It has been suggested that the doublets play a key role in the ability to synchronize over a distance. Here we analyze the mechanisms by which timing in the spike doublet can affect the synchronization process. The analysis describes two independent effects: one comes from the timing of excitation from separated local circuits to an inhibitory cell, and the other comes from the timing of inhibition from separated local circuits to an excitatory cell. We show that a network with both of these effects has different synchronization properties than a network with either excitatory or inhibitory type of coupling alone, and we give a rationale for the shorter space scales associated with inhibitory interactions.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Network of two coupled local circuits, each with one E and one I cell.
Figure 2
Figure 2
Latency to firing of I-cell after last received E-pulse. (A) Dependence on maximal excitatory conductance cei between circuits; gii = 0.15, gei = 0.2. (B) Dependence on inputs gei and gii to I cell within a circuit; cei = 0.1.
Figure 3
Figure 3
Latency to firing of E-cell after last received I-pulse. Discrete data points are computed from equations in Appendix. The three graphs correspond (top to bottom) to cei/gei = 1.0, 0.5, 0.25. Dashed lines for the top two are computed from formula 1 with τ = 20, tp = 25, tei = 1.5.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Traub R, Whittington M, Stanford M, Jefferys J. Nature (London) 1996;328:621–624. - PubMed
    1. Whittington M, Stanford I, Colling S, Jefferys J, Traub R. J Physiol. 1997;502:591–607. - PMC - PubMed
    1. Wang X J, Rinzel J. Neural Comp. 1992;4:84–97.
    1. Terman, D., Kopell, N. & Bose, A. (1998) Physica D, in press.
    1. van Vreeswijk C, Abbott L, Ermentrout G B. J Comput Neurosci. 1994;1:313–321. - PubMed

Publication types

LinkOut - more resources