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. 1997 Sep 15;57(1):1-18.
doi: 10.1016/s0198-8859(97)00175-4.

HLA class I polymorphism: structure and function and still questions

D D Kostyu  1 , L I Hannick, J L Traweek, M Ghanayem, D Heilpern, D V Dawson
Affiliations

HLA class I polymorphism: structure and function and still questions

D D Kostyu et al. Hum Immunol. .

Erratum in

  • Hum Immunol 1998 Jul;59(7):459-60

Abstract

The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alleles have now been defined prompted us to ask the question of where polymorphism really occurs in a class I molecule. We have used a database of 275 HLA-A, HLA-B and HLA-C alleles to illustrate how extensive the polymorphism is. The data is presented here for comparison of alleles and allele families and to facilitate studies of class I structure and function.

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