Review
doi: 10.1016/s0959-440x(97)80147-9.
GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins
Affiliations
- PMID: 9434896
- DOI: 10.1016/s0959-440x(97)80147-9
Item in Clipboard
Review
GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins
Curr Opin Struct Biol.
1997 Dec.
Abstract
Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated.
Similar articles
-
Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence.Biochemistry. 1996 Apr 9;35(14):4602-8. doi: 10.1021/bi951743d. Biochemistry. 1996. PMID: 8605211
-
A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs.Science. 1992 Oct 30;258(5083):812-5. doi: 10.1126/science.1439791. Science. 1992. PMID: 1439791
-
G proteins, effectors and GAPs: structure and mechanism.Curr Opin Struct Biol. 1997 Dec;7(6):849-56. doi: 10.1016/s0959-440x(97)80157-1. Curr Opin Struct Biol. 1997. PMID: 9434906 Review.
-
GAP into the breach.Science. 1997 Jul 18;277(5324):329-30. doi: 10.1126/science.277.5324.329. Science. 1997. PMID: 9518363 No abstract available.
-
The guanine nucleotide-binding switch in three dimensions.Science. 2001 Nov 9;294(5545):1299-304. doi: 10.1126/science.1062023. Science. 2001. PMID: 11701921 Review.
Cited by
-
Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.Compr Physiol. 2019 Dec 18;10(1):317-344. doi: 10.1002/cphy.c190014. Compr Physiol. 2019. PMID: 31853969 Free PMC article. Review.
-
Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function.EMBO J. 2001 Mar 1;20(5):961-70. doi: 10.1093/emboj/20.5.961. EMBO J. 2001. PMID: 11230120 Free PMC article.
-
Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation.J Biol Chem. 2009 Jul 3;284(27):18129-42. doi: 10.1074/jbc.M109.009597. Epub 2009 May 11. J Biol Chem. 2009. PMID: 19433581 Free PMC article.
-
Targeting an Essential GTPase Obg for the Development of Broad-Spectrum Antibiotics.PLoS One. 2016 Feb 5;11(2):e0148222. doi: 10.1371/journal.pone.0148222. eCollection 2016. PLoS One. 2016. PMID: 26848972 Free PMC article.
-
GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.Mol Cell Biol. 2003 Apr;23(7):2476-88. doi: 10.1128/MCB.23.7.2476-2488.2003. Mol Cell Biol. 2003. PMID: 12640130 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
