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. 1998 Jan 15;17(2):384-95.
doi: 10.1093/emboj/17.2.384.

Bim: a novel member of the Bcl-2 family that promotes apoptosis

L O'Connor  1 , A Strasser, L A O'Reilly, G Hausmann, J M Adams, S Cory, D C Huang
Affiliations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

L O'Connor et al. EMBO J. .

Abstract

Certain members of the Bcl-2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 homologues. Bim provokes apoptosis, and the BH3 region is required for Bcl-2 binding and for most of its cytotoxicity. Like Bcl-2, Bim possesses a hydrophobic C-terminus and localizes to intracytoplasmic membranes. Three Bim isoforms, probably generated by alternative splicing, all induce apoptosis, the shortest being the most potent. Wild-type Bcl-2 associates with Bim in vivo and modulates its death function, whereas Bcl-2 mutants that lack survival function do neither. Significantly, Bcl-xL and Bcl-w, the two closest homologues of Bcl-2, also bind to Bim and inhibit its activity, but more distant viral homologues, adenovirus E1B19K and Epstein-Barr virus BHRF-1, can do neither. Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family.

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References

    1. J Immunol Methods. 1991 Jun 3;139(2):271-9 - PubMed
    1. Cell. 1991 Nov 29;67(5):879-88 - PubMed
    1. Cell. 1991 Nov 29;67(5):889-99 - PubMed
    1. Mol Cell Biol. 1992 Jun;12(6):2570-80 - PubMed
    1. Science. 1992 May 15;256(5059):1014-8 - PubMed

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