Biphasic effect of hydrogen peroxide on field potentials in rat hippocampal slices
- PMID: 9430416
- DOI: 10.1016/s0014-2999(97)01323-x
Biphasic effect of hydrogen peroxide on field potentials in rat hippocampal slices
Abstract
In the CA1 region of rat hippocampal slices, H2O2 (0.294-2.94 mM) caused initial augmentation, and subsequent long-lasting depression, of population spikes and excitatory postsynaptic potentials. The effect of H2O2 may not be mediated by its degradation product, hydroxyl radicals, because an iron chelator deferoxamine did not block the effect. A catalase inhibitor 3-amino-1,2,4-triazole only modestly attenuated the initial augmentation, suggesting that the effect of H2O2 is not attributable to catalase-dependent O2 generation, either. An N-methyl-D-aspartate receptor antagonist DL-2-amino-5-phosphonovaleric acid had no influence on the effect of H2O2, whereas a gamma-aminobutyric acid type A receptor channel blocker picrotoxin attenuated long-lasting depression, indicating that gamma-aminobutyric acid-mediated inhibition is altered during the depression phase. The initial augmentation but not subsequent depression was attenuated by a phospholipase A2/C inhibitor 4-bromophenacyl bromide, suggesting the involvement of lipid signaling molecule(s) in the enhancement of excitatory synaptic transmission. These results suggest that H2O2 regulates hippocampal synaptic transmission via multiple mechanisms.
Similar articles
-
Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission.Hippocampus. 2004;14(3):319-25. doi: 10.1002/hipo.10176. Hippocampus. 2004. PMID: 15132431
-
Mechanisms underlying H(2)O(2)-mediated inhibition of synaptic transmission in rat hippocampal slices.Brain Res. 2000 Nov 3;882(1-2):86-94. doi: 10.1016/s0006-8993(00)02835-3. Brain Res. 2000. PMID: 11056187
-
Reactive oxygen species mediate the potentiating effects of ATP on GABAergic synaptic transmission in the immature hippocampus.J Biol Chem. 2006 Aug 18;281(33):23464-70. doi: 10.1074/jbc.M601627200. Epub 2006 Jun 20. J Biol Chem. 2006. PMID: 16787924
-
Influence of an extracellular acidosis on excitatory synaptic transmission and long-term potentiation in the CA1 region of rat hippocampal slices.J Neurosci Res. 2000 Nov 1;62(3):403-15. doi: 10.1002/1097-4547(20001101)62:3<403::AID-JNR11>3.0.CO;2-3. J Neurosci Res. 2000. PMID: 11054810
-
TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro.Neuroscience. 2012 Sep 18;220:70-84. doi: 10.1016/j.neuroscience.2012.06.028. Epub 2012 Jun 19. Neuroscience. 2012. PMID: 22728090
Cited by
-
Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress.J Neurosci. 1999 Nov 1;19(21):9209-17. doi: 10.1523/JNEUROSCI.19-21-09209.1999. J Neurosci. 1999. PMID: 10531424 Free PMC article.
-
Reactive oxygen species in the regulation of synaptic plasticity and memory.Antioxid Redox Signal. 2011 May 15;14(10):2013-54. doi: 10.1089/ars.2010.3208. Epub 2010 Oct 28. Antioxid Redox Signal. 2011. PMID: 20649473 Free PMC article. Review.
-
Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer's Disease.PLoS One. 2015 Aug 18;10(8):e0135686. doi: 10.1371/journal.pone.0135686. eCollection 2015. PLoS One. 2015. PMID: 26284625 Free PMC article.
-
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer's Disease.Cells. 2021 Jul 25;10(8):1884. doi: 10.3390/cells10081884. Cells. 2021. PMID: 34440653 Free PMC article. Review.
-
Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity.J Exp Neurosci. 2016 Sep 4;10(Suppl 1):23-48. doi: 10.4137/JEN.S39887. eCollection 2016. J Exp Neurosci. 2016. PMID: 27625575 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
