Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation
- PMID: 9395358
- DOI: 10.1086/514145
Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation
Abstract
Longitudinal analysis of 162 liver transplant recipients identified 51 patients who were viremic. Virus load was determined in 47 of these patients using quantitative-competitive polymerase chain reaction. Peak virus load was significantly higher in 20 symptomatic patients than 27 asymptomatic patients (P < .0001). Elevated virus load, donor seropositivity, and total methylprednisolone dosage were risk factors for human cytomegalovirus (HCMV) disease (odds ratio [OR], 2.22/0.25 log10 increase in virus load, P = .001; OR, 4.11, P = .05; OR, 1.30/1-g increment in methylprednisolone, P = .01). Methylprednisolone and virus load were independent risk factors in a multivariate analysis (OR, 2.70/1-g increase, P = .003; OR, 1.61/0.25 log10 increase, P = .03, respectively). Virus loads of 10(4.75)-10(5.25) genomes/mL of blood were associated with an increased disease probability; the latter was shifted to lower virus loads with increasing quantities of methylprednisolone. These data illustrate the central role of virus load in HCMV pathogenesis.
Similar articles
-
Relationship between IgM antibody to human cytomegalovirus, virus load, donor and recipient serostatus, and administration of methylprednisolone as risk factors for cytomegalovirus disease after liver transplantation.J Infect Dis. 2000 Dec;182(6):1610-5. doi: 10.1086/317636. Epub 2000 Oct 26. J Infect Dis. 2000. PMID: 11069231
-
Quantity of human cytomegalovirus (CMV) DNAemia as a risk factor for CMV disease in renal allograft recipients: relationship with donor/recipient CMV serostatus, receipt of augmented methylprednisolone and antithymocyte globulin (ATG).J Med Virol. 1999 Jun;58(2):182-7. J Med Virol. 1999. PMID: 10335868
-
Longitudinal fluctuations in cytomegalovirus load in bone marrow transplant patients: relationship between peak virus load, donor/recipient serostatus, acute GVHD and CMV disease.Bone Marrow Transplant. 1998 Mar;21(6):597-605. doi: 10.1038/sj.bmt.1701139. Bone Marrow Transplant. 1998. PMID: 9543064
-
Monitoring transplant patients for human cytomegalovirus: Diagnostic update.Herpes. 2006 May;13(1):4-11. Herpes. 2006. PMID: 16732996 Review.
-
[HCMV infections after hematopoietic stem cell transplantation--diagnostic methods and importance of viral DNA level monitoring].Postepy Hig Med Dosw (Online). 2015 Feb 21;69:252-63. doi: 10.5604/17322693.1141100. Postepy Hig Med Dosw (Online). 2015. PMID: 25720612 Review. Polish.
Cited by
-
Incidence of Cytomegalovirus disease and viral replication kinetics in seropositive liver transplant recipients managed under preemptive therapy in a tertiary-care center in Mexico City: a retrospective cohort study.BMC Infect Dis. 2022 Feb 14;22(1):155. doi: 10.1186/s12879-022-07123-w. BMC Infect Dis. 2022. PMID: 35164684 Free PMC article.
-
Choice of Study Populations for Vaccines.J Infect Dis. 2020 Mar 5;221(Suppl 1):S128-S134. doi: 10.1093/infdis/jiz537. J Infect Dis. 2020. PMID: 32134487 Free PMC article.
-
Why CMV is a candidate for elimination and then eradication.J Virus Erad. 2016 Jul 1;2(3):131-5. doi: 10.1016/S2055-6640(20)30455-6. J Virus Erad. 2016. PMID: 27482451 Free PMC article.
-
Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy.PLoS One. 2016 Sep 29;11(9):e0163722. doi: 10.1371/journal.pone.0163722. eCollection 2016. PLoS One. 2016. PMID: 27684379 Free PMC article.
-
Desirability and feasibility of a vaccine against cytomegalovirus.Vaccine. 2013 Apr 18;31 Suppl 2(Suppl 2):B197-203. doi: 10.1016/j.vaccine.2012.10.074. Vaccine. 2013. PMID: 23598482 Free PMC article. Review.
