Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine
- PMID: 9389785
Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine
Abstract
Intestinal epithelial cells (i-EC), which move to the villus tips from the crypts, rapidly die by apoptosis at the villus tips and are perpetually renewed at the crypts. To determine whether the Fas antigen (Fas)/Fas ligand (FasL) system is involved in the mechanism leading to apoptosis of i-EC, we examined the expression of Fas and FasL on the i-EC and intestinal intraepithelial lymphocytes (i-IEL) in normal mice. A high level of Fas was expressed on both the i-EC and i-IEL, whereas FasL was expressed in the i-IEL, especially in high-density fraction upon separation (high-density i-IEL), but not in the i-EC. The high-density i-IEL exhibited cytotoxicity against not only Fas transfectant but also the i-EC, and the cytotoxicity was inhibited by addition of Fas-Fragment c chimeric fusion protein. Thus, a significant fraction of i-IEL, such as high-density i-IEL, may partly contribute to induction of apoptosis in the effete i-EC via Fas/FasL interaction.
Similar articles
-
Anti-CD3 induces bi-phasic apoptosis in murine intestinal epithelial cells: possible involvement of the Fas/Fas ligand system in different T cell compartments.Int Immunol. 2005 May;17(5):513-22. doi: 10.1093/intimm/dxh231. Epub 2005 Mar 18. Int Immunol. 2005. PMID: 15778290
-
Intraepithelial lymphocyte-derived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in mice.Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G629-37. doi: 10.1152/ajpgi.00290.2002. Epub 2003 Jan 15. Am J Physiol Gastrointest Liver Physiol. 2003. PMID: 12529260
-
Fas/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis.J Immunol. 1998 Jul 1;161(1):241-51. J Immunol. 1998. PMID: 9647230
-
The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense.Immunol Res. 1999;20(3):219-35. doi: 10.1007/BF02790405. Immunol Res. 1999. PMID: 10741862 Review.
-
[Abnormal Fas and Fas ligand expression of lymphocytes in patients with SLE].Nihon Rinsho. 1996 Jul;54(7):1955-9. Nihon Rinsho. 1996. PMID: 8741694 Review. Japanese.
Cited by
-
Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.Curr Pathobiol Rep. 2018 Mar;6(1):35-46. Epub 2018 Jan 15. Curr Pathobiol Rep. 2018. PMID: 29755893 Free PMC article.
-
CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethality.Clin Diagn Lab Immunol. 2002 May;9(3):550-7. doi: 10.1128/cdli.9.3.550-557.2002. Clin Diagn Lab Immunol. 2002. PMID: 11986258 Free PMC article.
-
Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions.Infect Immun. 2000 Jul;68(7):4303-11. doi: 10.1128/IAI.68.7.4303-4311.2000. Infect Immun. 2000. PMID: 10858249 Free PMC article.
-
Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice.Immunology. 1999 May;97(1):92-9. doi: 10.1046/j.1365-2567.1999.00752.x. Immunology. 1999. PMID: 10447719 Free PMC article.
-
Intestinal damage in strongyloidiasis: the imbalance between cell death and proliferation.Dig Dis Sci. 2006 Jun;51(6):1063-9. doi: 10.1007/s10620-006-8010-2. Dig Dis Sci. 2006. PMID: 16865572
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous