This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 1997 Nov;86(11):1198-203.

doi: 10.1021/js970135b.

Phase separation of excipients during lyophilization: effects on protein stability

Affiliations

PMID: 9383725
DOI: 10.1021/js970135b

Review

Phase separation of excipients during lyophilization: effects on protein stability

T W Randolph. J Pharm Sci. 1997 Nov.

. 1997 Nov;86(11):1198-203.

doi: 10.1021/js970135b.

Author

Affiliation

¹ Department of Chemical Engineering, University of Colorado, Boulder 80309-0424, USA.

PMID: 9383725
DOI: 10.1021/js970135b

No abstract available

PubMed Disclaimer

Similar articles

Effects of excipients on the crystallization of pharmaceutical compounds during lyophilization.
Korey DJ, Schwartz JB. Korey DJ, et al. J Parenter Sci Technol. 1989 Mar-Apr;43(2):80-3. J Parenter Sci Technol. 1989. PMID: 2709239
Freeze-drying of proteins: some emerging concerns.
Roy I, Gupta MN. Roy I, et al. Biotechnol Appl Biochem. 2004 Apr;39(Pt 2):165-77. doi: 10.1042/BA20030133. Biotechnol Appl Biochem. 2004. PMID: 15032737 Review.
Conformational stability of lyophilized PEGylated proteins in a phase-separating system.
Heller MC, Carpenter JF, Randolph TW. Heller MC, et al. J Pharm Sci. 1999 Jan;88(1):58-64. doi: 10.1021/js980257j. J Pharm Sci. 1999. PMID: 9874703
Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins III: collapse during storage at elevated temperatures.
Schersch K, Betz O, Garidel P, Muehlau S, Bassarab S, Winter G. Schersch K, et al. Eur J Pharm Biopharm. 2013 Oct;85(2):240-52. doi: 10.1016/j.ejpb.2013.05.009. Epub 2013 May 31. Eur J Pharm Biopharm. 2013. PMID: 23727369
Rational design of stable lyophilized protein formulations: theory and practice.
Carpenter JF, Chang BS, Garzon-Rodriguez W, Randolph TW. Carpenter JF, et al. Pharm Biotechnol. 2002;13:109-33. doi: 10.1007/978-1-4615-0557-0_5. Pharm Biotechnol. 2002. PMID: 11987749 Review. No abstract available.

See all similar articles

Cited by

Application of the Thermal Analysis of Frozen Aqueous Solutions to Assess the Miscibility of Hyaluronic Acid and Polymers Used for Dissolving Microneedles.
Izutsu KI, Yoshida H, Abe Y, Yamamoto E, Sato Y, Ando D. Izutsu KI, et al. Pharmaceutics. 2024 Sep 30;16(10):1280. doi: 10.3390/pharmaceutics16101280. Pharmaceutics. 2024. PMID: 39458610 Free PMC article.
Storage and Lyophilization of Pure Proteins.
Ó'Fágáin C, Colliton K. Ó'Fágáin C, et al. Methods Mol Biol. 2023;2699:421-475. doi: 10.1007/978-1-0716-3362-5_19. Methods Mol Biol. 2023. PMID: 37647008
Molecular Dynamics Modeling Based Investigation of the Effect of Freezing Rate on Lysozyme Stability.
Duran T, Minatovicz B, Bellucci R, Bai J, Chaudhuri B. Duran T, et al. Pharm Res. 2022 Oct;39(10):2585-2596. doi: 10.1007/s11095-022-03358-z. Epub 2022 Aug 10. Pharm Res. 2022. PMID: 35948746
Armamentarium of Cryoprotectants in Peptide Vaccines: Mechanistic Insight, Challenges, Opportunities and Future Prospects.
Dalvi H, Bhat A, Iyer A, Sainaga Jyothi VGS, Jain H, Srivastava S, Madan J. Dalvi H, et al. Int J Pept Res Ther. 2021;27(4):2965-2982. doi: 10.1007/s10989-021-10303-y. Epub 2021 Oct 19. Int J Pept Res Ther. 2021. PMID: 34690621 Free PMC article. Review.
A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCT detecting malaria.
Ghosh S, Aggarwal K, U VT, Nguyen T, Han J, Ahn CH. Ghosh S, et al. Microsyst Nanoeng. 2020 Jan 27;6:5. doi: 10.1038/s41378-019-0108-8. eCollection 2020. Microsyst Nanoeng. 2020. PMID: 34567620 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
- Wiley
Other Literature Sources
- The Lens - Patent Citations