doi: 10.1126/science.278.5343.1612.
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
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- PMID: 9374458
- DOI: 10.1126/science.278.5343.1612
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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
Science.
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Abstract
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
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Pillars article: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997. 278: 1612-1615.J Immunol. 2013 Jan 1;190(1):16-9. J Immunol. 2013. PMID: 23264670 No abstract available.
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