Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Nov;61(5):1179-88.
doi: 10.1086/301592.

Allele-sharing models: LOD scores and accurate linkage tests

A Kong  1 , N J Cox
Affiliations

Allele-sharing models: LOD scores and accurate linkage tests

A Kong et al. Am J Hum Genet. 1997 Nov.

Abstract

Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously suggested approaches to handling less than perfectly informative data can be unacceptably conservative. Situations in which this model may not perform well are discussed, and an alternative model that requires additional computations is suggested.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biometrics. 1994 Mar;50(1):118-27 - PubMed
    1. Nat Genet. 1995 Nov;11(3):241-7 - PubMed
    1. Am J Hum Genet. 1996 Jun;58(6):1347-63 - PubMed
    1. Nat Genet. 1996 Jun;13(2):161-6 - PubMed
    1. Am J Hum Genet. 1996 Sep;59(3):704-16 - PubMed

Publication types

Substances

LinkOut - more resources