doi: 10.1038/nsb0997-686.
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
- PMID: 9302992
- DOI: 10.1038/nsb0997-686
Item in Clipboard
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
Nat Struct Biol.
1997 Sep.
Abstract
RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.
Similar articles
-
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.Science. 1997 Jul 18;277(5324):333-8. doi: 10.1126/science.277.5324.333. Science. 1997. PMID: 9219684
-
Structural basis unifying diverse GTP hydrolysis mechanisms.Biochemistry. 2013 Feb 12;52(6):1122-30. doi: 10.1021/bi3014054. Epub 2013 Jan 28. Biochemistry. 2013. PMID: 23293872
-
G proteins, effectors and GAPs: structure and mechanism.Curr Opin Struct Biol. 1997 Dec;7(6):849-56. doi: 10.1016/s0959-440x(97)80157-1. Curr Opin Struct Biol. 1997. PMID: 9434906 Review.
-
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.FEBS Lett. 2007 Dec 11;581(29):5677-84. doi: 10.1016/j.febslet.2007.11.026. Epub 2007 Nov 20. FEBS Lett. 2007. PMID: 18022389
-
Co-ordination and specificity of the action of GTPase-activating proteins and GDP/GTP-exchange factors on Ras.Biochem Soc Trans. 1997 Aug;25(3):997-1001. doi: 10.1042/bst0250997. Biochem Soc Trans. 1997. PMID: 9388589 Review. No abstract available.
Cited by
-
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras.Elife. 2022 Mar 11;11:e76595. doi: 10.7554/eLife.76595. Elife. 2022. PMID: 35272765 Free PMC article.
-
Biochemical dissection of the ATPase TraB, the VirB4 homologue of the Escherichia coli pKM101 conjugation machinery.J Bacteriol. 2010 May;192(9):2315-23. doi: 10.1128/JB.01384-09. Epub 2010 Feb 19. J Bacteriol. 2010. PMID: 20172994 Free PMC article.
-
Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.J Biol Chem. 2010 Jun 25;285(26):20155-63. doi: 10.1074/jbc.M110.114884. Epub 2010 Apr 21. J Biol Chem. 2010. PMID: 20410310 Free PMC article.
-
Dual role of DNA in regulating ATP hydrolysis by the SopA partition protein.J Biol Chem. 2009 Oct 30;284(44):30067-75. doi: 10.1074/jbc.M109.044800. Epub 2009 Sep 8. J Biol Chem. 2009. PMID: 19740757 Free PMC article.
-
A structural model of a Ras-Raf signalosome.Nat Struct Mol Biol. 2021 Oct;28(10):847-857. doi: 10.1038/s41594-021-00667-6. Epub 2021 Oct 8. Nat Struct Mol Biol. 2021. PMID: 34625747 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases
Miscellaneous