Regulation of aquaporin-2 water channel trafficking by vasopressin
- PMID: 9261056
- DOI: 10.1016/s0955-0674(97)80034-8
Regulation of aquaporin-2 water channel trafficking by vasopressin
Abstract
Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct. The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin. Recent studies have demonstrated that vasopressin, acting through cyclic AMP, triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells. The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process.
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