cGMP as second messenger during Dictyostelium chemotaxis
- PMID: 9247116
- DOI: 10.1016/s0014-5793(97)00416-x
cGMP as second messenger during Dictyostelium chemotaxis
Abstract
The chemoattractant cAMP induces directed cell locomotion in Dictyostelium cells. Several second messenger pathways are activated upon binding of cAMP to G-protein-coupled receptors, including adenylyl cyclase, guanylyl cyclase, phospholipase C, and the opening of plasma membrane Ca2+ channels. These second messenger responses are unaltered in many chemotactic mutants, except for the cGMP response. Activation of guanylyl cyclase depends on G-proteins and is regulated by a cGMP-binding protein in a complex manner. This cGMP-binding protein also mediates intracellular functions of cGMP to activate a PKC-related kinase that phosphorylates myosin II heavy chain, thereby allowing myosin filaments to rearrange during cell movement.
Similar articles
-
A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium.EMBO J. 2002 Sep 2;21(17):4560-70. doi: 10.1093/emboj/cdf438. EMBO J. 2002. PMID: 12198158 Free PMC article.
-
Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells.Experientia. 1995 Dec 18;51(12):1144-54. doi: 10.1007/BF01944732. Experientia. 1995. PMID: 8536802 Review.
-
Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction.J Cell Biol. 1993 Dec;123(6 Pt 1):1453-62. doi: 10.1083/jcb.123.6.1453. J Cell Biol. 1993. PMID: 7902839 Free PMC article.
-
Regulation of guanylyl cyclase by a cGMP-binding protein during chemotaxis in Dictyostelium discoideum.J Biol Chem. 1996 Sep 27;271(39):23718-24. doi: 10.1074/jbc.271.39.23718. J Biol Chem. 1996. PMID: 8798595
-
Unusual Guanylyl Cyclases and cGMP Signaling in Dictyostelium discoideum.Vitam Horm. 2004;69:95-115. doi: 10.1016/S0083-6729(04)69004-2. Vitam Horm. 2004. PMID: 15196880 Review.
Cited by
-
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.Mol Biol Cell. 1999 Sep;10(9):2829-45. doi: 10.1091/mbc.10.9.2829. Mol Biol Cell. 1999. PMID: 10473630 Free PMC article.
-
A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium.EMBO J. 2002 Sep 2;21(17):4560-70. doi: 10.1093/emboj/cdf438. EMBO J. 2002. PMID: 12198158 Free PMC article.
-
Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.Proc Natl Acad Sci U S A. 2000 May 9;97(10):5225-30. doi: 10.1073/pnas.97.10.5225. Proc Natl Acad Sci U S A. 2000. PMID: 10805781 Free PMC article.
-
Two Dictyostelium tyrosine kinase-like kinases function in parallel, stress-induced STAT activation pathways.Mol Biol Cell. 2014 Oct 15;25(20):3222-33. doi: 10.1091/mbc.E14-07-1182. Epub 2014 Aug 20. Mol Biol Cell. 2014. PMID: 25143406 Free PMC article.
-
Cyclic GMP and Cilia Motility.Cells. 2015 Jul 31;4(3):315-30. doi: 10.3390/cells4030315. Cells. 2015. PMID: 26264028 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
