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. 1997 Jun 27;89(7):1155-64.
doi: 10.1016/s0092-8674(00)80302-5.

Coassembly of TRP and TRPL produces a distinct store-operated conductance

X Z Xu  1 , H S Li, W B Guggino, C Montell
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Free article

Coassembly of TRP and TRPL produces a distinct store-operated conductance

X Z Xu et al. Cell. .
Free article

Abstract

The Drosophila retinal-specific protein, TRP (transient receptor potential), is the founding member of a family of store-operated channels (SOCs) conserved from C. elegans to humans. In vitro studies indicate that TRP is a SOC, but that the related retinal protein, TRPL, is constitutively active. In the current work, we report that coexpression of TRP and TRPL leads to a store-operated, outwardly rectifying current distinct from that owing to either TRP or TRPL alone. TRP and TRPL interact directly, indicating that the TRP-TRPL-dependent current is mediated by heteromultimeric association between the two subunits. We propose that the light-activated current in photoreceptor cells is produced by a combination of TRP homo- and TRP-TRPL heteromultimers.

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