Selective expression of adhesion molecules on human brain microvascular endothelial cells
- PMID: 9184636
- DOI: 10.1016/s0165-5728(97)00036-2
Selective expression of adhesion molecules on human brain microvascular endothelial cells
Abstract
Human microvascular endothelial cells were isolated from children's brain and examined for their morphological characteristics and upregulation of cell adhesion molecules in response to TNF alpha. Our human brain microvascular endothelial cells (HBMEC) were positive for factor VIII-Rag, carbonic anhydrase IV, Ulex Europeus Agglutinin I, took up fluorescently labeled acetylated low density lipoprotein and expressed gamma glutamyl transpeptidase, demonstrating their brain endothelial cell characteristics. Upon treatment with TNF alpha. VCAM and ICAM but little ELAM was expressed on HBMEC, while VCAM, ICAM and ELAM were clearly evident on HUVEC. This selective expression of cell adhesion molecules was also demonstrated by in situ stimulation of brain tissues. In conclusion, microvascular endothelial cells from childrens brains display selective expression of cell adhesion molecules, which differ from macrovascular endothelial cells. This may have consequences for leukocyte trafficking into the central nervous system.
Similar articles
-
VCAM-1-, ELAM-1-, and ICAM-1-independent adhesion of melanoma cells to cultured human dermal microvascular endothelial cells.J Invest Dermatol. 1992 Jan;98(1):79-85. doi: 10.1111/1523-1747.ep12495643. J Invest Dermatol. 1992. PMID: 1370233
-
Vascular adhesion molecules in oral lichen planus.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Jun;81(6):682-90. doi: 10.1016/s1079-2104(96)80074-6. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996. PMID: 8784900
-
Effects of antioxidants and NO on TNF-alpha-induced adhesion molecule expression in human pulmonary microvascular endothelial cells.Respir Med. 2005 May;99(5):580-91. doi: 10.1016/j.rmed.2004.10.007. Epub 2004 Nov 18. Respir Med. 2005. PMID: 15823455
-
Selective upregulation of intercellular adhesion molecule (ICAM-1) by ultraviolet B in human dermal microvascular endothelial cells.J Invest Dermatol. 1994 Jul;103(1):23-8. doi: 10.1111/1523-1747.ep12388971. J Invest Dermatol. 1994. PMID: 7517980
-
Regulation of adhesion receptors expression in endothelial cells.Curr Top Microbiol Immunol. 1993;184:87-98. doi: 10.1007/978-3-642-78253-4_7. Curr Top Microbiol Immunol. 1993. PMID: 8313725 Review. No abstract available.
Cited by
-
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response.Int J Mol Sci. 2022 Dec 30;24(1):656. doi: 10.3390/ijms24010656. Int J Mol Sci. 2022. PMID: 36614101 Free PMC article.
-
The Changes of P-glycoprotein Activity by Interferon-γ and Tumor Necrosis Factor-α in Primary and Immortalized Human Brain Microvascular Endothelial Cells.Biomol Ther (Seoul). 2012 May;20(3):293-8. doi: 10.4062/biomolther.2012.20.3.293. Biomol Ther (Seoul). 2012. PMID: 24130926 Free PMC article.
-
Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity.Glycoconj J. 2008 May;25(4):291-304. doi: 10.1007/s10719-007-9091-7. Epub 2008 Jan 5. Glycoconj J. 2008. PMID: 18176841
-
Caspr1 is a host receptor for meningitis-causing Escherichia coli.Nat Commun. 2018 Jun 12;9(1):2296. doi: 10.1038/s41467-018-04637-3. Nat Commun. 2018. PMID: 29895952 Free PMC article.
-
Photochemotherapeutic strategy against Acanthamoeba infections.Antimicrob Agents Chemother. 2015;59(6):3031-41. doi: 10.1128/AAC.05126-14. Epub 2015 Mar 9. Antimicrob Agents Chemother. 2015. PMID: 25753633 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
