Acute hypoxia stimulates renin secretion and renin gene expression in vivo but not in vitro
- PMID: 9140008
- DOI: 10.1152/ajpregu.1997.272.4.R1105
Acute hypoxia stimulates renin secretion and renin gene expression in vivo but not in vitro
Abstract
This study aimed at examining the influence of acute hypoxia on renin secretion and renin gene expression in the kidney. To this end, male Sprague-Dawley rats were exposed to severe hypoxic stress (8% O2) or to carbon monoxide (0.1% CO) for 6 h, and plasma renin activity (PRA) and renal renin mRNA levels were determined. PRA values increased from 3 to 13 and 10 ng angiotensin I x h(-1) x ml(-1), and renin mRNA levels increased by 120 and 100% during hypoxia and CO, respectively. Lowering the PO2 from 150 to 20 or 7 mmHg in the gas atmosphere of primary cultures of renal juxtaglomerular cells had no influence on renin secretion and renin gene expression after 6 and 20 h. Our findings thus suggest that both arterial and venous hypoxia can be powerful stimulators of renin secretion and renin gene expression in vivo. Because renal denervation did not prevent stimulation of the renin system by hypoxia, the effect could be indirectly mediated via the baroreceptor-macula densa mechanism. Another potential mediator of the effect could be circulating catecholamines, since we found that plasma norepinephrine increased from 0.7 to 1.5 and 2.4 ng/ml and plasma epinephrine increased from 0.3 to 1.4 and 2.7 ng/ml during hypoxia and CO inhalation, respectively.
Similar articles
-
Effects of hypoxia on renin secretion and renal renin gene expression.Kidney Int Suppl. 1998 Sep;67:S155-8. doi: 10.1046/j.1523-1755.1998.06732.x. Kidney Int Suppl. 1998. PMID: 9736275
-
T-type and L-type calcium channel blockers exert opposite effects on renin secretion and renin gene expression in conscious rats.Br J Pharmacol. 1998 Jun;124(3):579-85. doi: 10.1038/sj.bjp.0701861. Br J Pharmacol. 1998. PMID: 9647484 Free PMC article.
-
Sympathetic activation cannot fully account for increased plasma renin levels during water deprivation.Am J Physiol. 1997 Apr;272(4 Pt 2):R1197-203. doi: 10.1152/ajpregu.1997.272.4.R1197. Am J Physiol. 1997. PMID: 9140020
-
Regulation of renin synthesis in the juxtaglomerular cells.Curr Opin Nephrol Hypertens. 1996 Jan;5(1):16-9. doi: 10.1097/00041552-199601000-00005. Curr Opin Nephrol Hypertens. 1996. PMID: 8834157 Review.
-
Renin release: sites, mechanisms, and control.Annu Rev Physiol. 2011;73:377-99. doi: 10.1146/annurev-physiol-012110-142238. Annu Rev Physiol. 2011. PMID: 20936939 Review.
Cited by
-
Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCDcl1 Cells.Int J Mol Sci. 2022 Jun 30;23(13):7262. doi: 10.3390/ijms23137262. Int J Mol Sci. 2022. PMID: 35806266 Free PMC article.
-
Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat.Physiol Genomics. 2011 Jul 14;43(13):808-17. doi: 10.1152/physiolgenomics.00171.2010. Epub 2011 Apr 26. Physiol Genomics. 2011. PMID: 21521778 Free PMC article.
-
New Insights into the Mechanism by Which the Pituitary Gland Copes with Hypoxia Stress Based on a Transcriptomic Analysis of Megalobrama amblycephala.Genes (Basel). 2024 Jul 26;15(8):987. doi: 10.3390/genes15080987. Genes (Basel). 2024. PMID: 39202348 Free PMC article.
-
Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203.Int J Mol Sci. 2021 Sep 19;22(18):10127. doi: 10.3390/ijms221810127. Int J Mol Sci. 2021. PMID: 34576290 Free PMC article.
-
The prevalence of obstructive sleep apnea in interstitial lung disease: a systematic review and meta-analysis.Sleep Breath. 2021 Sep;25(3):1219-1228. doi: 10.1007/s11325-020-02282-z. Epub 2021 Jan 6. Sleep Breath. 2021. PMID: 33403599
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials