Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
- PMID: 9136933
- DOI: 10.1101/gad.11.8.1061
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
Abstract
The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the expression of a number of cardiac-specific genes. To determine the role of GATA4 in embryogenesis, we generated mice homozygous for a GATA4 null allele. Homozygous GATA4 null mice arrested in development between E7.0 and E9.5 because of severe developmental abnormalities. Mutant embryos most notably lacked a primitive heart tube and foregut and developed partially outside the yolk sac. In the mutants, the two bilaterally symmetric promyocardial primordia failed to migrate ventrally but instead remained lateral and generated two independent heart tubes that contained differentiated cardiomyocytes. We show that these deformities resulted from a general loss in lateral to ventral folding throughout the embryo. GATA4 is most highly expressed within the precardiogenic splanchnic mesoderm at the posterior lip of the anterior intestinal portal, corresponding to the region of the embryo that undergoes ventral fusion. We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP.
Similar articles
-
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.Genes Dev. 1997 Apr 15;11(8):1048-60. doi: 10.1101/gad.11.8.1048. Genes Dev. 1997. PMID: 9136932
-
Common role for each of the cGATA-4/5/6 genes in the regulation of cardiac morphogenesis.Dev Genet. 1998;22(3):263-77. doi: 10.1002/(SICI)1520-6408(1998)22:3<263::AID-DVG8>3.0.CO;2-4. Dev Genet. 1998. PMID: 9621433
-
Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse.Dev Biol. 1997 Sep 15;189(2):270-4. doi: 10.1006/dbio.1997.8684. Dev Biol. 1997. PMID: 9299119
-
GATA transcription factors and cardiac development.Semin Cell Dev Biol. 1999 Feb;10(1):85-91. doi: 10.1006/scdb.1998.0281. Semin Cell Dev Biol. 1999. PMID: 10355032 Review.
-
The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.J Biol Chem. 2000 Dec 15;275(50):38949-52. doi: 10.1074/jbc.R000029200. J Biol Chem. 2000. PMID: 11042222 Review. No abstract available.
Cited by
-
Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex.Int J Mol Sci. 2022 Nov 19;23(22):14388. doi: 10.3390/ijms232214388. Int J Mol Sci. 2022. PMID: 36430866 Free PMC article. Review.
-
Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harb Perspect Med. 2013 Sep 1;3(9):a015412. doi: 10.1101/cshperspect.a015412. Cold Spring Harb Perspect Med. 2013. PMID: 23838521 Free PMC article. Review.
-
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.PLoS Genet. 2012;8(5):e1002690. doi: 10.1371/journal.pgen.1002690. Epub 2012 May 10. PLoS Genet. 2012. PMID: 22589735 Free PMC article.
-
Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system.Theranostics. 2024 Aug 12;14(12):4894-4915. doi: 10.7150/thno.92060. eCollection 2024. Theranostics. 2024. PMID: 39239522 Free PMC article.
-
GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.Endocrinology. 2012 Jun;153(6):2599-611. doi: 10.1210/en.2011-2135. Epub 2012 Mar 28. Endocrinology. 2012. PMID: 22461617 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
