Review
doi: 10.1016/s0952-7915(97)80144-6.
Positive selection of thymocytes bearing alpha beta T cell receptors
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- PMID: 9099796
- DOI: 10.1016/s0952-7915(97)80144-6
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Review
Positive selection of thymocytes bearing alpha beta T cell receptors
Curr Opin Immunol.
1997 Apr.
Abstract
The past year has been marked by the application of new technologies to study thymocyte development. These studies have shown that positive selection affects a surprisingly large proportion of thymocytes, and now are beginning to investigate the affinities/avidities of the reactions involved. The lengthy controversy over how thymocytes decide whether to express CD4 or CD8 has taken a new turn with the discovery that levels of expression of the fate-determining protein Notch may affect the decision.
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