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. 1997 Mar 7;88(5):593-602.
doi: 10.1016/s0092-8674(00)81902-9.

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

M Serrano  1 , A W Lin, M E McCurrach, D Beach, S W Lowe
Affiliations
Free article

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

M Serrano et al. Cell. .
Free article

Abstract

Oncogenic ras can transform most immortal rodent cells to a tumorigenic state. However, transformation of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16. Here we show that expression of oncogenic ras in primary human or rodent cells results in a permanent G1 arrest. The arrest induced by ras is accompanied by accumulation of p53 and p16, and is phenotypically indistinguishable from cellular senescence. Inactivation of either p53 or p16 prevents ras-induced arrest in rodent cells, and E1A achieves a similar effect in human cells. These observations suggest that the onset of cellular senescence does not simply reflect the accumulation of cell divisions, but can be prematurely activated in response to an oncogenic stimulus. Negation of ras-induced senescence may be relevant during multistep tumorigenesis.

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Comment in

  • Senescence: back to telomeres.
    Jacobs JJ. Jacobs JJ. Nat Rev Mol Cell Biol. 2013 Apr;14(4):196. doi: 10.1038/nrm3544. Epub 2013 Mar 6. Nat Rev Mol Cell Biol. 2013. PMID: 23463217 No abstract available.

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