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Comment

. 1997 Mar 4;94(5):1615-8.

doi: 10.1073/pnas.94.5.1615.

Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing

D Unutmaz¹, D R Littman

Affiliations

PMID: 9050826
PMCID: PMC34141
DOI: 10.1073/pnas.94.5.1615

Comment

Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing

D Unutmaz et al. Proc Natl Acad Sci U S A. 1997.

. 1997 Mar 4;94(5):1615-8.

doi: 10.1073/pnas.94.5.1615.

Authors

D Unutmaz¹, D R Littman

Affiliation

¹ Skirball Institute for BioMolecular Medicine, New York University Medical Center, New York, NY 10016, USA.

PMID: 9050826
PMCID: PMC34141
DOI: 10.1073/pnas.94.5.1615

No abstract available

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Figures

Figure 1
Model for transmission of HIV-1. In this model of HIV pathogenesis, the infection is restricted to M-tropic viruses, which use CCR5 and CD4 for entry into target cells. Infection of macrophages/DC and memory T cell conjugates activates macrophage/DC, which in turn stimulate memory T cells. These conjugates allow productive HIV replication of M-tropic strains that eventually evolve into T-tropic or dual-tropic (strains using both coreceptors) viruses.

See this image and copyright information in PMC

Comment on

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. Bleul CC, et al. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1925-30. doi: 10.1073/pnas.94.5.1925. Proc Natl Acad Sci U S A. 1997. PMID: 9050881 Free PMC article.

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