Review
doi: 10.1016/s0952-7915(97)80166-5.
Regulation of transcription of MHC class II genes
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- PMID: 9039770
- DOI: 10.1016/s0952-7915(97)80166-5
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Review
Regulation of transcription of MHC class II genes
Curr Opin Immunol.
1997 Feb.
Abstract
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.
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