Regulation of telomere length and function by a Myb-domain protein in fission yeast
- PMID: 9034194
- DOI: 10.1038/385744a0
Regulation of telomere length and function by a Myb-domain protein in fission yeast
Abstract
Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic chromosomes, are essential for complete replication, and regulation of their length has been a focus of research on tumorigenesis. In the budding yeast Saccharomyces cerevisiae, the protein Rap1p binds to telomeric DNA and functions in the regulation of telomere length. A human telomere protein, hTRF (human TTAGGG repeat factor) binds the telomere sequence in vitro and localizes to telomeres cytologically, but its functions are not yet known. Here we use a genetic screen to identify a telomere protein in fission yeast, Taz1p (telomere-associated in Schizosaccharomyces pombe), that shares homology to the Myb proto-oncogene DNA-binding domain with hTRF. Disruption or deletion of the taz1+ gene causes a massive increase in telomere length. Taz1p is required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation.
Comment in
-
Telomeres. Different means to common ends.Nature. 1997 Feb 20;385(6618):676-7. doi: 10.1038/385676a0. Nature. 1997. PMID: 9034181 No abstract available.
Similar articles
-
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.Nat Genet. 1997 Oct;17(2):231-5. doi: 10.1038/ng1097-231. Nat Genet. 1997. PMID: 9326950
-
Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding.Nucleic Acids Res. 2007;35(4):1333-42. doi: 10.1093/nar/gkm043. Epub 2007 Jan 31. Nucleic Acids Res. 2007. PMID: 17272298 Free PMC article.
-
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination.Nature. 1998 Apr 23;392(6678):828-31. doi: 10.1038/33947. Nature. 1998. PMID: 9572143
-
Telomere length regulation: getting the measure of chromosome ends.Biol Chem. 1997 Jul;378(7):591-7. Biol Chem. 1997. PMID: 9278138 Review.
-
Telomeres and telomerase in Candida albicans.Mycoses. 2012 May;55(3):e48-59. doi: 10.1111/j.1439-0507.2011.02123.x. Epub 2011 Oct 10. Mycoses. 2012. PMID: 21981562 Review.
Cited by
-
Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.Biochemistry. 2016 Sep 27;55(38):5326-40. doi: 10.1021/acs.biochem.6b00496. Epub 2016 Sep 15. Biochemistry. 2016. PMID: 27575340 Free PMC article.
-
Minishelterins separate telomere length regulation and end protection in fission yeast.Genes Dev. 2015 Jun 1;29(11):1164-74. doi: 10.1101/gad.261123.115. Genes Dev. 2015. PMID: 26063574 Free PMC article.
-
To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Front Biosci (Landmark Ed). 2010 Jun 1;15(3):1105-18. doi: 10.2741/3664. Front Biosci (Landmark Ed). 2010. PMID: 20515744 Free PMC article. Review.
-
Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.Mol Cell Biol. 2005 Oct;25(20):8887-903. doi: 10.1128/MCB.25.20.8887-8903.2005. Mol Cell Biol. 2005. PMID: 16199868 Free PMC article.
-
Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility.Chromosoma. 2007 Feb;116(1):41-51. doi: 10.1007/s00412-006-0081-5. Epub 2006 Nov 7. Chromosoma. 2007. PMID: 17089138 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
