doi: 10.1038/385602a0.
Crystal structure of the Src family tyrosine kinase Hck
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- PMID: 9024658
- DOI: 10.1038/385602a0
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Crystal structure of the Src family tyrosine kinase Hck
Nature.
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Abstract
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
Comment in
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New impressions of Src and Hck.Nature. 1997 Feb 13;385(6617):582-3, 585. doi: 10.1038/385582b0. Nature. 1997. PMID: 9024653 No abstract available.
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