Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis
- PMID: 9020075
- DOI: 10.1126/science.275.5302.960
Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis
Abstract
The mechanisms responsible for thyrocyte destruction in Hashimoto's thyroiditis (HT) are poorly understood. Thyrocytes from HT glands, but not from nonautoimmune thyroids, expressed Fas. Interleukin-1beta (IL-1beta), abundantly produced in HT glands, induced Fas expression in normal thyrocytes, and cross-linking of Fas resulted in massive thyrocyte apoptosis. The ligand for Fas (FasL) was shown to be constitutively expressed both in normal and HT thyrocytes and was able to kill Fas-sensitive targets. Exposure to IL-1beta induced thyrocyte apoptosis, which was prevented by antibodies that block Fas, suggesting that IL-1beta-induced Fas expression serves as a limiting factor for thyrocyte destruction. Thus, Fas-FasL interactions among HT thyrocytes may contribute to clinical hypothyroidism.
Comment in
- Science. 1998 Mar 27;279(5359):2015
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Thyroid disease: a case of cell suicide?Science. 1997 Feb 14;275(5302):926. doi: 10.1126/science.275.5302.926. Science. 1997. PMID: 9053994 No abstract available.
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