Review
doi: 10.1016/s0968-0004(96)20026-x.
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs
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- PMID: 9009826
- DOI: 10.1016/s0968-0004(96)20026-x
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Review
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs
Trends Biochem Sci.
1996 Dec.
Free article
Abstract
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.
Comment in
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Why do protein kinase cascades have more than one level?Trends Biochem Sci. 1997 Aug;22(8):288. doi: 10.1016/s0968-0004(97)82216-5. Trends Biochem Sci. 1997. PMID: 9270298 No abstract available.
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