A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
- PMID: 8980230
- DOI: 10.1016/s0092-8674(00)81819-x
A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
Abstract
In a screen for genes that interact with the Rap1 GTPase, we have identified a Drosophila gene, dacapo (dap), which is a member of the p21/p27 family of cdk inhibitors. Unlike mammalian cdk inhibitors studied to date, dap is essential for normal embryonic development. Dacapo inhibits cyclin-cdk activity in vitro. Overexpressing dap during eye development interferes with cell cycle progression and interacts genetically with the retinoblastoma homolog (Rbf) and cyclin E. dap expression in embryos parallels the exit of cells from the cell cycle. dap mutant embryos delay the normal cell cycle exit during development; many cells complete an additional cycle and subsequently become quiescent. Thus, dap functions during embryogenesis to achieve a precisely timed exit from the cell cycle.
Similar articles
-
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.Cell. 1996 Dec 27;87(7):1225-35. doi: 10.1016/s0092-8674(00)81818-8. Cell. 1996. PMID: 8980229
-
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.Cell. 1994 Jul 15;78(1):67-74. doi: 10.1016/0092-8674(94)90573-8. Cell. 1994. PMID: 8033213
-
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.Genes Dev. 1995 Mar 15;9(6):650-62. doi: 10.1101/gad.9.6.650. Genes Dev. 1995. PMID: 7729684
-
Regulation of the embryonic cell proliferation by Drosophila cyclin D and cyclin E complexes.Novartis Found Symp. 2001;237:43-54; discussion 54-7, 93-9. doi: 10.1002/0470846666.ch5. Novartis Found Symp. 2001. PMID: 11444049 Review.
-
The cell cycle kinases.Semin Cancer Biol. 1994 Aug;5(4):305-13. Semin Cancer Biol. 1994. PMID: 7803767 Review.
Cited by
-
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression.EMBO J. 2000 Sep 1;19(17):4533-42. doi: 10.1093/emboj/19.17.4533. EMBO J. 2000. PMID: 10970847 Free PMC article.
-
Ectopic expression of the Drosophila Cdk1 inhibitory kinases, Wee1 and Myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development.Genetics. 2002 Jun;161(2):721-31. doi: 10.1093/genetics/161.2.721. Genetics. 2002. PMID: 12072468 Free PMC article.
-
The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes.Plant Cell. 2005 Jun;17(6):1723-36. doi: 10.1105/tpc.105.032383. Epub 2005 Apr 29. Plant Cell. 2005. PMID: 15863515 Free PMC article.
-
Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles.J Cell Biol. 1997 Oct 6;139(1):13-21. doi: 10.1083/jcb.139.1.13. J Cell Biol. 1997. PMID: 9314525 Free PMC article.
-
Cdks and the Drosophila cell cycle.Curr Opin Genet Dev. 1997 Feb;7(1):17-22. doi: 10.1016/s0959-437x(97)80104-9. Curr Opin Genet Dev. 1997. PMID: 9024630 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
