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. 1996 Dec;20(12):1051-4.

Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet

F Fumeron  1 , I Durack-Bown, D Betoulle, A M Cassard-Doulcier, S Tuzet, F Bouillaud, J C Melchior, D Ricquier, M Apfelbaum
Affiliations
  • PMID: 8968848

Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet

F Fumeron et al. Int J Obes Relat Metab Disord. 1996 Dec.

Abstract

Objective: To investigate whether the genetic polymorphisms of the uncoupling protein (UCP) and beta 3 adrenergic receptor (beta 3 AR) were associated with differences of weight loss in obese patients submitted to a low calorie diet.

Design: Longitudinal, clinical intervention study of a 25% restriction in energy intake with respect to genotypes.

Subjects: 163 patients with a body mass index above 27.

Measurements: Body weight and body mass index at baseline and after 2.5 months, genotypes by polymerase chain reaction followed by enzymatic digestion.

Results: For the UCP polymorphism, two alleles, 1 and 2 were identified with respective frequencies of 0.27 and 0.73. The allele 1 was associated with lower body weight loss after diet: 4,6,5.7 and 7.1 kg for the 1-1, 1-2 and 2-2 genotypes respectively (P < 0.05). No difference in weight loss was found according to the beta 3 AR Trp64Arg mutation.

Conclusions: A genetic variant of the UCP gene is associated with a resistance to low calorie diet. This result, together with previous data on body weight gain, supports the hypothesis of a role of UCP and brown adipose tissue in the body weight regulation in humans. The importance of the Trp64Arg mutation of the beta 3 AR in the resistance to low calorie diet is still to demonstrate.

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