doi: 10.1038/384432a0.
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
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- PMID: 8945469
- DOI: 10.1038/384432a0
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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
Nature.
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Abstract
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
Comment in
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Reversal of fortune for nascent proteins.Nature. 1996 Dec 5;384(6608):405-6. doi: 10.1038/384405a0. Nature. 1996. PMID: 8945460 No abstract available.
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