Interacting signaling pathways controlling multicellular development in Dictyostelium
- PMID: 8939724
- DOI: 10.1016/s0959-437x(96)80082-7
Interacting signaling pathways controlling multicellular development in Dictyostelium
Abstract
cAMP functions as the key extracellular signaling molecule controlling Dictyostelium development acting through classic G-protein-coupled/serpentine receptors. Whereas aggregation is controlled by nanomolar pulses of cAMP, a more continuous micromolar signal controls multicellular differentiation by activating a transcriptional cascade via a receptor-mediated but non G-protein-coupled pathway. Potential mechanisms by which extracellular cAMP functions to differentially control aggregation followed by morphogenesis and cell-type differentiation are discussed. This review also summarizes new findings elucidating pathways controlling cell-type regulation in this organism, including signaling cascades mediated by glycogen synthase kinase 3 and cAMP-dependent protein kinase, key regulators of cell-type differentiation in metazoans, and newly identified transcription factors.
Similar articles
-
Signal transduction pathways controlling multicellular development in Dictyostelium.Trends Genet. 1991 Nov-Dec;7(11-12):381-8. doi: 10.1016/0168-9525(91)90260-w. Trends Genet. 1991. PMID: 1668191 Review.
-
A role for cAMP-dependent protein kinase A in early Dictyostelium development.Genes Dev. 1990 Jan;4(1):18-28. doi: 10.1101/gad.4.1.18. Genes Dev. 1990. PMID: 1968413
-
cAMP signal transduction pathways regulating development of Dictyostelium discoideum.Curr Opin Genet Dev. 1991 Oct;1(3):383-90. doi: 10.1016/s0959-437x(05)80304-1. Curr Opin Genet Dev. 1991. PMID: 1668648 Review.
-
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.Dev Biol. 1997 Mar 15;183(2):208-21. doi: 10.1006/dbio.1996.8499. Dev Biol. 1997. PMID: 9126295
-
G alpha 3 regulates the cAMP signaling system in Dictyostelium.Mol Biol Cell. 1997 Sep;8(9):1677-85. doi: 10.1091/mbc.8.9.1677. Mol Biol Cell. 1997. PMID: 9307965 Free PMC article.
Cited by
-
A developmentally regulated kinesin-related motor protein from Dictyostelium discoideum.Mol Biol Cell. 1998 Aug;9(8):2093-106. doi: 10.1091/mbc.9.8.2093. Mol Biol Cell. 1998. PMID: 9693369 Free PMC article.
-
Cell signaling during development of Dictyostelium.Dev Biol. 2014 Jul 1;391(1):1-16. doi: 10.1016/j.ydbio.2014.04.001. Epub 2014 Apr 12. Dev Biol. 2014. PMID: 24726820 Free PMC article. Review.
-
Becoming Multicellular by Aggregation; The Morphogenesis of the Social Amoebae Dicyostelium discoideum.J Biol Phys. 2002 Dec;28(4):765-80. doi: 10.1023/A:1021259326918. J Biol Phys. 2002. PMID: 23345812 Free PMC article.
-
KeaA, a Dictyostelium Kelch-domain protein that regulates the response to stress and development.BMC Dev Biol. 2010 Jul 29;10:79. doi: 10.1186/1471-213X-10-79. BMC Dev Biol. 2010. PMID: 20670432 Free PMC article.
-
Role for YakA, cAMP, and protein kinase A in regulation of stress responses of Dictyostelium discoideum cells.Mol Biol Cell. 2002 Jul;13(7):2266-75. doi: 10.1091/mbc.01-11-0555. Mol Biol Cell. 2002. PMID: 12134067 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
