Long-term impact of clozapine and psychosocial treatment on psychiatric symptoms and cognitive functioning
- PMID: 8925344
- DOI: 10.1176/ps.47.1.41
Long-term impact of clozapine and psychosocial treatment on psychiatric symptoms and cognitive functioning
Abstract
Objective: The long-term effects of a combination of clozapine and psychosocial treatment were evaluated in a sample of treatment-refractory state hospital patients with schizophrenia.
Methods: A repeated-measure design was used. Thirty-one patients with schizophrenia received both clozapine and an enhanced psychosocial treatment program. Data were collected at baseline and at one-year, two-year, and three-year follow-ups. Psychiatric symptoms, cognitive functioning, dyskinetic movements, and discharge rate were evaluated.
Results: Significant reductions in psychiatric symptoms and improvement in cognitive functioning were found. Differences in the pattern of reductions in positive and negative symptoms over the course of the study were noted. The majority of subjects improved sufficiently to be discharged.
Conclusions: Clozapine, when combined with psychosocial treatment, is effective for treatment of patients with schizophrenia who are not responsive to other medications.
Similar articles
-
Effectiveness of clozapine and a social learning program for severely disabled psychiatric inpatients.Psychiatr Serv. 1996 Jan;47(1):46-51. doi: 10.1176/ps.47.1.46. Psychiatr Serv. 1996. PMID: 8925345
-
Effects of switching inpatients with treatment-resistant schizophrenia from clozapine to risperidone.Psychiatr Serv. 1996 Dec;47(12):1382-4. doi: 10.1176/ps.47.12.1382. Psychiatr Serv. 1996. PMID: 9117479
-
Effects of clozapine for non-treatment-resistant patients with schizophrenia.Psychiatr Serv. 1999 Jan;50(1):101-3. doi: 10.1176/ps.50.1.101. Psychiatr Serv. 1999. PMID: 9890589
-
Combination of clozapine and amisulpride in treatment-resistant schizophrenia--case reports and review of the literature.Pharmacopsychiatry. 2004 Jan;37(1):26-31. doi: 10.1055/s-2004-815471. Pharmacopsychiatry. 2004. PMID: 14750045 Review.
-
The effects of clozapine on cognitive functioning in schizophrenia.J Clin Psychiatry. 1999;60 Suppl 12:24-9. J Clin Psychiatry. 1999. PMID: 10372607 Review.
Cited by
-
Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis.Psychopharmacology (Berl). 2010 Mar;208(4):531-43. doi: 10.1007/s00213-009-1754-6. Epub 2009 Dec 30. Psychopharmacology (Berl). 2010. PMID: 20041229
-
Predictors and markers of clozapine response.Psychopharmacology (Berl). 2005 May;179(2):317-35. doi: 10.1007/s00213-005-2174-x. Epub 2005 Feb 17. Psychopharmacology (Berl). 2005. PMID: 15717209 Review.
-
Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine.Transl Psychiatry. 2016 Apr 19;6(4):e784. doi: 10.1038/tp.2016.51. Transl Psychiatry. 2016. PMID: 27093066 Free PMC article.
-
Starting clozapine in the community: a UK perspective.CNS Drugs. 2004;18(13):845-52. doi: 10.2165/00023210-200418130-00002. CNS Drugs. 2004. PMID: 15521789 Review.
-
Antipsychotic Drugs and Cognitive Function: A Systematic Review and Network Meta-Analysis.JAMA Psychiatry. 2025 Jan 1;82(1):47-56. doi: 10.1001/jamapsychiatry.2024.2890. JAMA Psychiatry. 2025. PMID: 39412783
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical