Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996;34(1):22-5.
doi: 10.1159/000119286.

Effects of carbamazepine and sodium valproate on 5-HT-induced calcium increase in individual C6 rat glioma cells

T Yamaji  1 , A Kagaya, Y Uchitomi, N Yokata, S Yamawaki
Affiliations

Effects of carbamazepine and sodium valproate on 5-HT-induced calcium increase in individual C6 rat glioma cells

T Yamaji et al. Neuropsychobiology. 1996.

Abstract

The effects of drugs for affective disorders on the sustained phase of serotonin (5-HT)-induced calcium (Ca2+) response were investigated in single C6BU-1 glioma cells with digital imaging microscopy. The sustained phase was significantly attenuated by 32 microM carbamazepine and 320 microM sodium valproate as well as 100 nM clomipramine and verapamil, whose effects we evaluated in our previous report. The present findings demonstrate that drugs for affective disorders, in their therapeutic concentrations, have common action of inhibiting Ca2+ influx, and suggest that the Ca2+ antagonistic effect may play an important role in the mechanism of the action sites of the drugs for affective disorders.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources