Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1996 Jul;2(4):405-12.

SOX genes: architects of development

H M Prior  1 , M A Walter
Affiliations
Review

SOX genes: architects of development

H M Prior et al. Mol Med. 1996 Jul.

Abstract

Development in higher organisms involves complex genetic regulation at the molecular level. The emerging picture of development control includes several families of master regulatory genes which can affect the expression of down-stream target genes in developmental cascade pathways. One new family of such development regulators is the SOX gene family. The SOX genes are named for a shared motif called the SRY box a region homologous to the DNA-binding domain of SRY, the mammalian sex determining gene. Like SRY, SOX genes play important roles in chordate development. At least a dozen human SOX genes have been identified and partially characterized (Tables 1 and 2). Mutations in SOX9 have recently been linked to campomelic dysplasia and autosomal sex reversal, and other SOX genes may also be associated with human disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1991 May 9;351(6322):117-21 - PubMed
    1. Am J Med Genet. 1983 May;15(1):3-28 - PubMed
    1. Nature. 1992 Feb 13;355(6361):635-6 - PubMed
    1. Nucleic Acids Res. 1992 Jun 11;20(11):2887 - PubMed
    1. EMBO J. 1992 Aug;11(8):3039-44 - PubMed

Publication types

MeSH terms

LinkOut - more resources