The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions
- PMID: 8797828
- DOI: 10.1016/s0092-8674(00)80156-7
The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions
Abstract
We have discovered that all known yeast and vertebrate small nucleolar RNAs (snoRNAs), except for the MRP/7-2 RNA, fall into two major classes. One class is defined by conserved boxes C and D and the other by a novel element: a consensus ACA triplet positioned 3 nt before the 3' end of the RNA. A role for the ACA box is snoRNA stability has been established by mutational analysis of a yeast ACA snoRNA (snR 11). Full function of the box depends on the integrity of an adjacent upstream stem. All members of the yeast ACA family are associated with the GAR1 protein. Binding of this or another common small nucleolar ribonucleoprotein particle protein is predicted to be a critical entry point to snoRNA posttranscriptional life, including precise formation of the snoRNA 3' end.
Similar articles
-
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation.Genes Dev. 1997 Apr 1;11(7):941-56. doi: 10.1101/gad.11.7.941. Genes Dev. 1997. PMID: 9106664
-
Accumulation of H/ACA snoRNPs depends on the integrity of the conserved central domain of the RNA-binding protein Nhp2p.Nucleic Acids Res. 2001 Jul 1;29(13):2733-46. doi: 10.1093/nar/29.13.2733. Nucleic Acids Res. 2001. PMID: 11433018 Free PMC article.
-
Identification and functional analysis of a novel yeast small nucleolar RNA.Nucleic Acids Res. 1993 Nov 25;21(23):5386-90. doi: 10.1093/nar/21.23.5386. Nucleic Acids Res. 1993. PMID: 8265353 Free PMC article.
-
The vertebrate E1/U17 small nucleolar ribonucleoprotein particle.J Cell Biochem. 2006 Jun 1;98(3):486-95. doi: 10.1002/jcb.20821. J Cell Biochem. 2006. PMID: 16475166 Review.
-
The role of small nucleolar ribonucleoproteins in ribosome synthesis.Mol Biol Rep. 1990;14(2-3):103-6. doi: 10.1007/BF00360433. Mol Biol Rep. 1990. PMID: 2141891 Review. No abstract available.
Cited by
-
Regulation of snoRNAs in cancer: close encounters with interferon.J Interferon Cytokine Res. 2013 Apr;33(4):189-98. doi: 10.1089/jir.2012.0106. J Interferon Cytokine Res. 2013. PMID: 23570385 Free PMC article. Review.
-
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10.Mol Cell Biol. 2000 Dec;20(23):9028-40. doi: 10.1128/MCB.20.23.9028-9040.2000. Mol Cell Biol. 2000. PMID: 11074001 Free PMC article.
-
Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3'-processing apparatus.EMBO J. 2000 Nov 15;19(22):6218-29. doi: 10.1093/emboj/19.22.6218. EMBO J. 2000. PMID: 11080167 Free PMC article.
-
An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.Mol Biol Cell. 2004 Jun;15(6):2842-52. doi: 10.1091/mbc.e04-02-0116. Epub 2004 Apr 9. Mol Biol Cell. 2004. PMID: 15075370 Free PMC article.
-
Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea.Nucleic Acids Res. 2003 Feb 1;31(3):869-77. doi: 10.1093/nar/gkg175. Nucleic Acids Res. 2003. PMID: 12560482 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
