doi: 10.1111/j.1600-0684.1995.tb00159.x.
Assessing genetic-based therapies for AIDS using the simian immunodeficiency virus
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- PMID: 8751053
- DOI: 10.1111/j.1600-0684.1995.tb00159.x
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Assessing genetic-based therapies for AIDS using the simian immunodeficiency virus
J Med Primatol.
1995 May.
Abstract
A plasmid encoding the full-length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient co-transfection studies were initiated with the infectious proviral clone and a well-characterized trans-dominant negative HIV-1 rev mutant.
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