Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1996 Feb;29(2):244-50.
doi: 10.1006/faat.1996.0028.

Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis

J Cao  1 , Y Xu, J Chen, J E Klaunig
Affiliations
Comparative Study

Chemopreventive effects of green and black tea on pulmonary and hepatic carcinogenesis

J Cao et al. Fundam Appl Toxicol. 1996 Feb.

Abstract

The chemopreventive effects of decaffeinated green and black tea treatment on liver and lung tumorigenesis were examined in carcinogen-treated mice. Male C3H mice were given decaffeinated green or decaffeinated black tea in their drinking water prior to, during, and after treatment with diethylnitrosamine (50 micrograms/kg bw, i.p., once per week for 8 weeks). After 40 weeks of tea treatment, mice were sampled and examined for pulmonary and hepatic tumors. Mice treated with both DENA and tea displayed a significant decrease in the mean number of lung and liver tumors compared to DENA-only treated animals. Mice that received 0.63 or 1.25% green tea or 1.25% black tea exhibited a reduction in liver tumor numbers of 54, 50, and 63%, respectively from that seen in the DENA-only treated mice. Tea treatment also significantly decreased the multiplicity of lung adenomas. Mice receiving DENA and either 0.63 or 1.25% green tea or 1.25% black tea showed a decrease in the mean number of lung tumors of 40, 46, and 34%, respectively, from DENA-only treated mice. While a possible association between the chemopreventive activity of tea on lung tumor response and the concentration of (-) epigallocatechin gallate (EGCG) in the tea was suggested, no apparent relationship between EGCG concentration and liver tumor response was seen, however. These results show a dose-dependent chemoprevention of both lung and liver tumors by both black and green tea in diethylnitrosamine-treated C3H mice.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources