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Review
. 1996 Mar;19(6):1167-75.
doi: 10.1111/j.1365-2958.1996.tb02462.x.

The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs

I T Paulsen  1 , R A Skurray, R Tam, M H Saier Jr, R J Turner, J H Weiner, E B Goldberg, L L Grinius
Affiliations
Review

The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs

I T Paulsen et al. Mol Microbiol. 1996 Mar.

Abstract

The sequenced members of a novel family of small, hydrophobic, bacterial multidrug-resistance efflux proteins, which we have designated the small multidrug resistance (SMR) protein family, are identified and analysed. Two distinct clusters of proteins were identified within this family: (i) small multidrug efflux systems; and (ii) Sug proteins, potentially involved in the suppression of groEL mutations. Hydropathy and residue distribution analyses of this family suggest a structural model in which the polypeptide chain spans the membrane four times as mildly amphipathic alpha-helices. The roles of specific residues, a possible mechanistic model of drug efflux, and the primary physiological role(s) of the SMR proteins are discussed.

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