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. 1996 Aug;2(8):906-11.
doi: 10.1038/nm0896-906.

Large clonal expansions of CD8+ T cells in acute infectious mononucleosis

M F Callan  1 , N Steven, P Krausa, J D Wilson, P A Moss, G M Gillespie, J I Bell, A B Rickinson, A J McMichael
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Large clonal expansions of CD8+ T cells in acute infectious mononucleosis

M F Callan et al. Nat Med. 1996 Aug.

Abstract

Primary infection with Epstein-Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, the nature of which has been controversial. We show that large monoclonal or oligoclonal populations of CD8+ T cells account for a significant proportion of the lymphocytosis and provide molecular evidence that these populations have been driven by antigen. The results suggest that the selective and massive expansion of a few dominant clones of CD8+ T cells is an important feature of the primary response to this virus.

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